Dear All: 

Institute of Molecular Medicine
School of Life Sciences
Center for Life Sciences
Research Seminar

 

Title🙇🏽‍♀️：Transcriptional regulation in cardiovascular system development and disease

Speaker：William T. Pu, M.D.

                Professor of Pediatrics

                Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, USA

Time👨🏿‍🚀：2016年6月22日（星期三）下午1:00-2:30

Place：北京大学金光生命科学大楼101报告厅

Host💂🏿：北京大学分子医学研究所     何爱彬(Tel. 6276-7275)

Abstract: Formation and function of the cardiovascular system is under exquisite transcriptional control. Using a combination of functional genetic, transcriptomic, and epigenomic approaches the Pu lab has been investigating the molecular mechanisms of transcriptional regulation in the heart and vascular systems. In this talk I will summarize some of the findings: (1) mapping of dynamic changes in transcription factor complexes and binding sites through heart development and disease; (2) post-transcriptional regulation of transcription factor complexes in and their effects on heart growth; and (3) development of a Cre-directed method for cell type specific enhancer identification and its application to studying transcriptional regulation of blood vessel formation and homeostasis.